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$375,000
226028496 MLS
Ideally positioned along the highly sought-after Alico Road corridor in South Fort Myers, 17030 Alico Road benefits from exceptional connectivity and proximity to some of Southwest Florida's most significant commercial, residential, and employment hubs. The property is located just east of the interchange with Interstate 75 and minutes from Southwest Florida International Airport, providing convenient regional and national access. The site is surrounded by major amenities, including Gulf Coast Town Center, featuring over 100 retail stores, restaurants, entertainment venues, and national retailers, as well as nearby Florida Gulf Coast University and numerous hotels, office campuses, industrial parks, and rapidly expanding residential communities. Its strategic location offers direct access to major transportation corridors including Alico Road (CR 840), Ben Hill Griffin Parkway, and Interstate 75, positioning the property at the center of one of Southwest Florida's fastest-growing mixed-use and logistics corridors.

17030 Alico Commerce Ct Unit 303, Fort Myers
$350,000
226028486 MLS
Ideally positioned along the highly sought-after Alico Road corridor in South Fort Myers, 17030 Alico Road benefits from exceptional connectivity and proximity to some of Southwest Florida's most significant commercial, residential, and employment hubs. The property is located just east of the interchange with Interstate 75 and minutes from Southwest Florida International Airport, providing convenient regional and national access. The site is surrounded by major amenities, including Gulf Coast Town Center, featuring over 100 retail stores, restaurants, entertainment venues, and national retailers, as well as nearby Florida Gulf Coast University and numerous hotels, office campuses, industrial parks, and rapidly expanding residential communities. Its strategic location offers direct access to major transportation corridors including Alico Road (CR 840), Ben Hill Griffin Parkway, and Interstate 75, positioning the property at the center of one of Southwest Florida's fastest-growing mixed-use and logistics corridors.

17030 Alico Commerce Ct Unit 3200, Fort Myers
$310,000
226028308 MLS
Experience the timeless appeal of this 1,553 SF office building located at 2023 Jeffcott St in Fort Myers, FL. Originally constructed in 1939 and revitalized in 2026, this property seamlessly blends historic charm with modern functionality. Zoned CI, it offers a versatile space ideal for various office or co-working configurations. The strategic location within the City of Fort Myers area ensures excellent accessibility from Cleveland Ave (US 41). With its rich history, recent updates, and prime zoning, this property presents an exceptional opportunity for office users looking to establish or expand their presence in this vibrant market. Priced very competitively as one of very few small free-standing office properties in the area. Sold as vacant for immediate occupancy.

2023 Jeffcott St, Fort Myers
$4,970,000
226027899 MLS ⋅ Mcgregor Village BLDG.
Welcome to McGregor Village! A charming neighborhood center that has recently undergone a transformative development. It is now a vibrant new center with a village-like feel, making it an increasingly desirable place to run your business from. This center offers pylon signage & easy access from both College Pkwy and McGregor Blvd. It also provides plenty of parking, lush landscaping and a great tenant mix of retail, office and restaurant(s). This center consists of 10 buildings and also includes the addresses of 9280-9290 College Pkwy (it is listed under the same parcel ID#)

12709-12731 Mcgregor Blvd, Fort Myers
$11
2026030892 MLS
FOR LEASE! Ideally located at a signalized intersection on Colonial Boulevard and Deleon St. Traffic 54,000 Cars per day Near US41 / Cleveland Ave 2 story, it can be converted as separated properties, downstairs and upstairs, with 2 different entrances. Excellent exposure Signage opportunity on busy Colonial Boulevard

1705 Colonial Blvd Unit D2, Fort Myers
-$1
2026030769 MLS
Position your practice for success in this highly desirable, move-in-ready medical office condo situated within a premier, established professional medical park. Located on the ground floor for effortless patient access, Suite #105 offers an ideal layout for a variety of healthcare practitioners, specialists, or wellness providers looking to capture a robust Southwest Florida demographic.Strategically situated just off Metro Parkway, one of Fort Myers’ most heavily traveled professional corridors. The property features seamless connectivity to major thoroughfares, including Six Mile Cypress Parkway, Colonial Boulevard, and US-41, ensuring a painless commute for patients coming from Cape Coral, Estero, or Downtown Fort Myers. Located just minutes away from Gulf Coast Medical Center, allowing for efficient hospital rounds and coordinated patient care.

14131 Metropolis Ave Unit 105, Fort Myers
$2,495,000
2026026549 MLS
A rare opportunity to secure one of the most visible and strategically positioned commercial assemblages on Sanibel Island's iconic Periwinkle Way corridor. Offering approximately 150 feet of prime frontage along the island's primary commercial artery, 1444 and 1446 Periwinkle Way present a unique chance to shape the future of one of Sanibel's most recognizable locations. The combined offering includes three existing structures spread across two commercial parcels, creating exceptional flexibility for investors, owner-users, developers, retailers, restaurants, garden concepts, professional offices, wellness destinations, galleries, showrooms, mixed-use redevelopment, and countless other possibilities. Imagine revitalizing the existing buildings into a collection of charming Old Florida commercial spaces, creating an inviting courtyard-style destination, or starting fresh with a completely new vision designed to maximize visibility, parking, and customer experience along one of the island's highest traffic corridors. Opportunities of this scale, frontage, and flexibility rarely become available on Sanibel, where commercial land has historically remained tightly held for decades. There has never been a more exciting time to invest in Sanibel's future. The island is experiencing a remarkable rebirth as businesses rebuild, reinvent, and reimagine what comes next. New concepts, new architecture, and new energy are returning to the Sanctuary Island, creating an environment unlike any other point in recent history. As long-established properties transition to new ownership and new ideas, buyers have a rare opportunity to become part of the next chapter of Sanibel's commercial evolution. Adjacent to the Bailey Homestead Preserve and Garden Center and neighboring the lands of SCCF, this highly visible location combines natural beauty with exceptional exposure and accessibility. Whether your vision is restoration, redevelopment, investment, or creating an entirely new island destination, 1444 and 1446 Periwinkle Way offer the location, flexibility, and visibility to bring that vision to life. Prime commercial frontage. Exceptional visibility. Endless possibilities. The future of Sanibel is being written now and this is your opportunity to help shape it.

1446 Periwinkle Way, Sanibel
$1,072,000
2026029707 MLS
3,634 two unit building in good condition located in CRA district. The property is zoned SC which is a very flexible zoning. The property has been previously used as an insurance office, Real Estate office, Deli, and now has one unit being used a a Bakery. The Bakery tenant's lease ends at the end of August 2026. They would like to stay on. The property can be used as three units. Excellent opportunity for owner occupant or investors. The property is in good condition and is being sold AS IS.

1615 Se 47th Ter, Cape Coral
$629,000
226025383 MLS
Excellent Location with Easy Access to Central Fort Myers and Cape Coral 59,400 Cars Per Day 2025 (TCDS) Lee County 9 Parking Spaces, Plus 4 Shared Electronic Pylon Signage

1625 Colonial Blvd, Fort Myers
$2,450
2026029093 MLS
This 1,015 sf second floor office space located at 923 Del Prado Blvd. S. in the Southeast section of Cape Coral, Florida. This unit will be available in October 2026 but could be available sooner. Office includes a lobby, reception area, storage, 3 private offices, conference room, kitchenette with full size refrigerator, storage closet/ file station. Windows face south overlooking the parking lot. Easy access from all 3 streets, Del Prado Blvd, Viscaya Pkwy. and SE 16th Place. Great parking and signage.

923 Del Prado S Blvd Unit 203, Cape Coral
$1,295,000
2026028619 MLS
Exceptional Investment Opportunity! Don’t miss this fully leased, 100% occupied professional office building offering immediate and reliable income. Currently configured as five well-appointed units, with the potential to expand to seven, this property features a strong roster of mostly long-term tenants, providing stability and peace of mind for investors. Meticulously maintained, the building is truly turnkey, boasting a new roof, new A/C systems, and updated plumbing—minimizing future capital expenses. Its prime location in the heart of Cape Coral on Lafayette Street ensures excellent visibility, accessibility, and continued demand. Whether you are expanding your portfolio or seeking a solid income-producing asset, this property delivers outstanding value and long-term potential. Opportunities like this are rare—act quickly!

1314-1322 Lafayette St Unit A, Cape Coral
$3,350,000
226024833 MLS
Premier Commercial is pleased to present the exclusive opportunity to acquire Tamiami Plaza, located at 16251 N. Cleveland Avenue in North Fort Myers, Florida. This multi-tenant commercial/medical building encompasses approximately 20,532 square feet and is occupied by nine (9) tenants. The property’s tenant mix is anchored by necessity-based healthcare and personal services businesses, delivering a diversified and stable income stream. The property is zoned C-1 (Neighborhood Commercial) and approved for a broad range of office, medical office, and retail uses, providing flexibility for future leasing without rezoning. Tenants benefit from direct US-41 frontage, a fully signalized intersection, double curb cut access, available building signage, and on-site parking spaces. A full roof replacement completed in December 2025, backed by a 20-Year No Dollar Limit (NDL) Warranty, significantly reduces near-term capital expenditure risk for the incoming owner. Situated along North Cleveland Avenue / US-41 with traffic counts of approximately 27,000 vehicles per day, the property benefits from premier frontage in one of North Fort Myers’ busiest commercial corridors. The surrounding trade area features a strong mix of retail, service, and residential uses, supported by the greater Fort Myers MSA population of approximately 860,000 residents and continued regional healthcare expansion.

16251 N Cleveland Ave, North Fort Myers
$1,175,000
226024831 MLS
Premier Commercial, Inc. is pleased to present the exclusive opportunity to acquire 16101 N. Cleveland Avenue, a ±5,741 SF single-tenant medical building 100% leased to DaVita Dialysis (NYSE: DVA), one of the world’s largest and most respected kidney care providers. Strategically positioned along US-41 in North Fort Myers, Florida, the property delivers stabilized, passive income backed by a Fortune 500 healthcare tenant operating in a mission-critical, recession-resistant industry. The property is secured by a Triple Net (NNN) lease running through November 30, 2030, providing long term, stable cashflow. Tenant responsibilities cover interior maintenance, HVAC, utilities, and non-structural elements, while landlord obligations are limited to the building shell and structural components. The roof was fully replaced in January 2017, significantly reducing near-term capital exposure and reinforcing the passive nature of ownership. Situated along North Cleveland Avenue / US-41 with traffic counts of approximately 27,000 vehicles per day, the property benefits from premier frontage in one of North Fort Myers’ busiest commercial corridors. The surrounding trade area features a strong mix of retail, service, and residential uses, supported by the greater Fort Myers MSA population of approximately 860,000 residents and continued regional healthcare expansion.

16101 N Cleveland Ave Unit 251, North Fort Myers
$16
2026027955 MLS
Key West Style office units available for lease. Located in Central Fort Myers, just off Summerlin Rd., between Colonial Blvd. and Boy Scout Dr. New Metal Roofs on all buildings. Unit 42-1 | 1,315 SF | $19.00 PSF + $7.90 CAM | Professional Office. Fully Built-Out. (3) Offices, Wood Flooring, Conf Room, Kitchenette, & 2 Restrooms. Unit 40-2 | 1,870 SF | $16.00 PSF + $7.90 CAM | Unfinished former Dental Office with negotiable rent and build-out costs. Unit 42-1 | 1,315 SF | Professional Office. Fully Built-Out. (3) Offices, Wood Flooring, Conf Room, Kitchenette, & 2 Restrooms. Parking Spaces: Ample – Shared

40 Barkley Cir Unit 40-2 & 42-1, Fort Myers
-$1
2026027358 MLS
Position your business for success in this centrally located Fort Myers office space. Formerly used as a dental laboratory, this adaptable suite offers endless possibilities for medical, healthcare, wellness, laboratory, or professional office users. The space is delivered without equipment, providing a blank canvas to design the ideal environment for your practice or business. Located just minutes from downtown Fort Myers, major transportation routes, restaurants, and professional services, this property offers convenience, visibility, and accessibility. Whether you're expanding an existing business or launching a new venture, this flexible office space presents an excellent opportunity in a highly desirable location.

1949 Maravilla Ave, Fort Myers
$1,395
2026027731 MLS ⋅ Home Hunters Usa BLDG.
CENTER OF LEE COUNTY on Colonial Blvd. **45,000 car a DAY!! Great exposure! Office is neat and clean and ready for new tenant/leasee ! Water/Sewer is PAID!

1415 Colonial Blvd Unit 2, Fort Myers
$479,900
226023712 MLS
Banyan Creek Business Center is a professional office park designed in charming Key West style buildings, located off Old McGregor Blvd. The building is configured as one office but has the potential to be divided into two separate units. The existing layout includes a reception area, 8 private offices, 6 with windows and two without, 2 large spacious open work areas, a breakroom and 4 private restrooms. The building is move-in ready, featuring new floors and paint throughout. The property is ideally located just minutes away from Health Park Medial Center & Golisano Children’s Hospital, Sanibel Island and Fort Myers Beach.

12855 Banyan Creek Dr Unit 109-110, Fort Myers
$369,000
2026026479 MLS
Position your business or investment in a professionally updated office condominium located in one of Sanibel's most active commercial districts. This corner office condominium is one of only two commercial units in the plaza offering the largest floor plan, with approximately 1,200 square feet of air-conditioned space within a five-unit, partially elevated building that has been recently renovated with a new shingle roof and firewalls between each office condominium. Located at the end of the plaza, the corner location provides additional privacy, abundant natural light through extra windows and convenient parking for customers and staff. The current layout includes a reception area, three private offices and a private half bath, offering flexibility for a variety of professional and service-oriented businesses. Just steps from Jerry's Foods, this highly visible mid-island location benefits from consistent local traffic and convenient accessibility for island residents and visitors. The plaza has historically accommodated a diverse mix of successful businesses, including accounting, chiropractic, veterinary, wellness, real estate and vacation rental operations. For investors, the current tenant is on a month-to-month lease and has expressed willingness to execute a lease renewal, creating a potential opportunity for immediate income. Monthly condominium fees of $750 include building insurance, water, sewer, trash service and pest control, helping simplify ownership and operating expenses. Whether seeking a space for your professional service or medical business, a satellite office or income-producing investment, this office condominium offers a flexible floor plan, established commercial presence and a central Sanibel location.

1640 Periwinkle Way Unit 5, Sanibel
-$1
2026026175 MLS
Prime professional office space now available for lease at 45 Barkley Circle, Fort Myers, FL. This beautifully maintained unit features 7 private offices, 3 bathrooms, and an oversized break room, ideal for a growing professional practice. The space has been freshly painted throughout and is move-in ready. Previously built for a dental office. Building highlights include a new roof replacement (2025), 4 A/C units ensuring optimal climate control, and 15 parking spaces including 4 covered spaces for staff or clients. Situated in one of Fort Myers' most sought-after corridors for professional and medical offices, this location offers unmatched convenience with easy access to major roadways and surrounding amenities. Do not miss this opportunity to position your business in a premier professional setting. Schedule a showing today!

45 Barkley Cir, Fort Myers
-$1
226022524 MLS
Available: STE 1 on October 1, 2026. Individual office entrance, reception, 5 offices, kitchenette, storage closets and restroom. Lease Rate: $16.00 PSF + NNN (est. $7.07 PSF).

11922 Fairway Lakes Dr, Fort Myers
$4,500,000
226021642 MLS
ABSOLUTELY STUNNING “CLASS A” QUALITY, 6100 SQUARE FOOT FLEX BUILDING IN PRIME LOCATION OFFERING IMPRESSIVE SPACE FOR OFFICE, SHOWROOM, CORPORATE HOSPITALITY, WAREHOUSE, LIGHT INDUSTRIAL MEDICAL AND MORE!! This is an outstanding opportunity for any business wanting to STAND OUT from the crowd and make a SOLID AND GRAND FIRST IMPRESSION! Building is currently setup with a large and gorgeous reception with soaring 18 ft. coffered ceilings, 9 private offices of various sizes (all wired with RJ45 connectors), 2 top-tier kitchens, large entertaining flex space off the main kitchen, huge flex/warehouse/storage space, large garage/receiving/warehouse space with 14 ft overhead door and 4 luxury bathrooms. Building has been modernized and lavishly updated over the past few years including new marble flooring, crown moulding, interior and exterior paint, interior and exterior lighting, 2 new kitchens, all new bathrooms, “statement piece” 12 ft tall, iron entry double doors, remote blinds, plantation shutters, epoxy garage floor, new tankless water heater, all new landscaping and much more! Roof was done in 2017 and all windows are impact rated! Plenty of parking with wide parking spots for 20+ cars. Concealed Dumpster area in place. Building is located in an ideal setting of Vanderbilt Office Park providing peace and tranquility but just steps to Vanderbilt Beach Road with convenient access to both Bonita Springs and Naples!! Perfectly placed in the corner of the business park this building offers privacy form the neighboring buildings. Annual Fees for Vanderbilt Office park are $2,000.0.00 per year. Call for a private showing of this truly special offering!!

Bonita Springs
$1,500
2026023987 MLS
**Location, Location, Location!** Looking for the perfect location for your office? Look no further! Situated in the heart of downtown Cape Coral's CRA District, this prime ground-floor office space offers outstanding visibility and convenience. Located near Big John's Plaza, across from The Dek Bar, and just moments from the intersection of Cape Coral Parkway and Del Prado Boulevard, this is an ideal location for meeting clients and growing your business. The office features a welcoming reception/entry area, two private offices, a kitchenette/bar area with refrigerator, and hurricane-impact windows and doors throughout. Clients and staff will appreciate the ample street parking directly in front of the building, along with dedicated parking spaces for tenants. As an added bonus, a brand-new Mediterranean restaurant is opening right next door, bringing even more energy and convenience to this thriving business district. Whether you're expanding your business, opening a satellite office, or seeking a professional space in one of Cape Coral's most desirable commercial locations, this opportunity is not to be missed. **Location, Location, Location — establish your business in the center of Cape Coral's continued growth and success!** Conveniently located just off Cape Coral Parkway and Del Prado Boulevard in the heart of Southeast Cape Coral. Easy access for clients coming from Cape Coral Parkway, Del Prado Boulevard, Fort Myers, and surrounding areas. Situated near restaurants, professional offices, retail shops, and downtown Cape Coral amenities. Excellent visibility with convenient access and nearby parking. Directions: From Cape Coral Parkway, turn onto SE 15th Avenue and continue approximately two blocks north. Property is located on the right-hand corner of SE 15th Avenue and SE 47th Street. From Del Prado Boulevard, turn west onto SE 47th Street. Property is located at the corner of SE 47th Street and SE 15th Avenue.

4645 Se 15th Ave, Cape Coral
$399,000
2026020327 MLS
Great opportunity to purchase this medical office located in the heart of Fort Myers and only blocks away from the new Lee Health Hospital projected to open in 2028. This unit offers a reception area, admin office with storage/file room, three treatment rooms, open flex space with sinks, kitchenette, outdoor terrace under truss and ample parking. Pylon signage available.

4968 Royal Gulf Cir, Fort Myers
-$1
2026020407 MLS
Professional business complex in the heart of Fort Myers Available for immediate occupancy Professional or medical office spaces with multiple layouts Central location provides easy access Property is equidistant to all the main arteries of Fort Myers: US-41, Colonial Blvd.? and Winkler Ave Plenty of parking Drive around access Unit 15 can be built to Tenants specifications - 2,150/SF Unit 6 - 1,000/SF

3660 Central Ave Unit 6, Fort Myers
-$1
225083722 MLS
PERFECT AT PARKER COMMONS!! With its ample parking, high ceilings, 2 separate entrances, hard surface flooring throughout and completely flexible floorplan easily tailored to your needs, you have found the perfect space for your business!! Office/Medical space in well maintained business center, located on the Daniels Corridor conveniently between US 41 & 75. Available for immediate occupancy!!

13411 Parker Commons Blvd Unit 103, Fort Myers
-$1
226016861 MLS
Morse Shores Professional Center is a very well-maintained neighborhood center located on Palm Beach Blvd. just minutes from Downtown Fort Myers and close to I-75. This is a multi-tenant building consisting of (4) separate units. Unit 3 is 1,500± SF and currently available for lease. The layout consists of a reception desk and waiting area, 5 private offices, a file / storage room or additional office, a conference room, and large breakroom and restroom. Highlights - Well Maintained Neighborhood Center - Great Location - Minutes from Downtown Fort Myers or I-75 - High Traffic Volume

4857 Palm Beach Blvd Unit 3, Fort Myers
$759,900
2026017647 MLS
Opportunity for an owner occupant or investor. One unit is leased to a spa until 2028 with the other unit available for occupancy by an owner or lease it out. This property is zoned for office/medical. The units are updated and show well. The World Plaza is located in South Fort Myers with easy access to US41 and all the major corridors. Plenty of parking availability. This community has onsite professional management and is well kept. The Seller's unit has 2 restrooms as well as 2 showers. It includes a kitchen, a large conference area and several offices plus a front desk reception area and a nice size waiting area. The spa has several treatment rooms, two restrooms, a small kitchen area, front desk/waiting area. Total square footage of both units is 3,264 sf.

12545 New Brittany Blvd Unit 551, Fort Myers
$3,471
2026017728 MLS
Available now, grey shell 1323 square foot space in newer construction building. Prime medical/office space right on Bonita Beach Road.

11380 Bonita Beach Se Rd, Bonita Springs
$51
226015028 MLS
Hard-to-find small retail space at Bonita's newest retail address! Building complete - moving tenants in now! 800sf +/- with direct frontage on Bonita Beach Road. Delivered as a vanilla shell with HVAC and handicap bathroom - ready on or about June 1st, 2026. High ceilings, lots of natural light, plenty of parking, and large sign panel. Offered at $3,900/month gross (includes CAM).

12611 Bonita Beach Se Rd, Bonita Springs
-$1
226015024 MLS
Discover the prime location of 2104 Del Prado Blvd S in Cape Coral, FL, the heart of Southwest Florida's vibrant retail scene. Surrounded by high-traffic areas and within close proximity to popular attractions like Tarpon Point Marina, Cape Harbor, and Cape Coral Yacht Club, this area offers an unmatched opportunity for retail and street retail tenants. With a mix of residential neighborhoods and a steady flow of tourists, the location provides a steady stream of potential customers. The area's strong demographics and bustling commercial activity make it an ideal setting for your retail business to thrive.

2104 Del Prado S Blvd, Cape Coral