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40 Barkley Cir Unit 40-2, Fort Myers
$16
2026027955 MLS
Lovely One level Key West Style office units available for lease. Located in Fort Myers, just off Summerlin Rd., between Colonial Blvd. and Boy Scout Dr. New Metal Roofs on all buildings. Unit 40-2 | 1,870 SF | $16.00 PSF + $7.90 CAM | $3,724.41/mth. for the first year. Needs complete renovation. Unfinished former Dental Office with negotiable rent and build-out costs and incentives. Parking Spaces: Ample – Shared. Zoning is NC - Neighborhood Commercial

40 Barkley Cir Unit 40-2, Fort Myers
1949 Maravilla Ave, Fort Myers
$?
2026027358 MLS
Position your business for success in this centrally located Fort Myers office space. Formerly used as a dental laboratory, this adaptable suite offers endless possibilities for medical, healthcare, wellness, laboratory, or professional office users. The space is delivered without equipment, providing a blank canvas to design the ideal environment for your practice or business. Located just minutes from downtown Fort Myers, major transportation routes, restaurants, and professional services, this property offers convenience, visibility, and accessibility. Whether you're expanding an existing business or launching a new venture, this flexible office space presents an excellent opportunity in a highly desirable location.

1949 Maravilla Ave, Fort Myers
1415 Colonial Blvd Unit 2, Fort Myers
$1,395
2026027731 MLS ⋅ Home Hunters Usa BLDG.
CENTER OF LEE COUNTY on Colonial Blvd. **45,000 car a DAY!! Great exposure! Office is neat and clean and ready for new tenant/leasee ! Water/Sewer is PAID!

1415 Colonial Blvd Unit 2, Fort Myers
1025 2nd St, Fort Myers Beach
$800,000
2026027588 MLS
This commercial lot is located in the heart of Time Square adjacent to Harbour House at the Inn on Ft Myers Beach. The downtown commercial zoning will allow for a variety of commercial use. Downtown zoning multi-uses include residential, lodging, office restaurant and retail. The seller has provided a mixed-use concept with commercial on the ground level and 6 - 1 bedroom condo/ hotel rooms on the 2nd & 3rd floor. This is one of the lowest priced properties for development within the high traffic area of Downtown Fort Myers Beach!

1025 2nd St, Fort Myers Beach
12855 Banyan Creek Dr Unit 109-110, Fort Myers
$479,900
226023712 MLS
Banyan Creek Business Center is a professional office park designed in charming Key West style buildings, located off Old McGregor Blvd. The building is configured as one office but has the potential to be divided into two separate units. The existing layout includes a reception area, 8 private offices, 6 with windows and two without, 2 large spacious open work areas, a breakroom and 4 private restrooms. The building is move-in ready, featuring new floors and paint throughout. The property is ideally located just minutes away from Health Park Medial Center & Golisano Children’s Hospital, Sanibel Island and Fort Myers Beach.

12855 Banyan Creek Dr Unit 109-110, Fort Myers
1625 Hendry St Unit 400, Fort Myers
$?
226023705 MLS
An unique opportunity to occupy the 4th floor in the Historic Rob & Stucky Building, a renowned century old landmark in the heart of Downtown Fort Myers. High ceilings, historic charm, and modern upgrades meet at Suite 400 in the Historic Robb & Stucky Building. This professional office space is just steps from the Lee County Courthouse and adjacent to the Downtown restaurants, shops, and amenities. Enjoy the privacy of an exclusive full-floor office, complete with brand-new impact windows that bring in stunning natural light and overlook Hendry Street. Plus, parking is a breeze with the Denison Main Street Garage situated right behind the building.

1625 Hendry St Unit 400, Fort Myers
1640 Periwinkle Way Unit 5, Sanibel
$325,000
2026026479 MLS
Position your business or investment in a professionally updated office condominium located in one of Sanibel's most active commercial districts. This corner office condominium is one of only two commercial units in the plaza offering the largest floor plan, with approximately 1,200 square feet of air-conditioned space within a five-unit, partially elevated building that has been recently renovated with a new shingle roof and firewalls between each office condominium. Located at the end of the plaza, the corner location provides additional privacy, abundant natural light through extra windows and convenient parking for customers and staff. The current layout includes a reception area, three private offices and a private half bath, offering flexibility for a variety of professional and service-oriented businesses. Just steps from Jerry's Foods, this highly visible mid-island location benefits from consistent local traffic and convenient accessibility for island residents and visitors. The plaza has historically accommodated a diverse mix of successful businesses, including accounting, chiropractic, veterinary, wellness, real estate and vacation rental operations. For investors, the current tenant is on a month-to-month lease and has expressed willingness to execute a lease renewal, creating a potential opportunity for immediate income. Monthly condominium fees of $750 include building insurance, water, sewer, trash service and pest control, helping simplify ownership and operating expenses. Whether seeking a space for your professional service or medical business, a satellite office or income-producing investment, this office condominium offers a flexible floor plan, established commercial presence and a central Sanibel location.

1640 Periwinkle Way Unit 5, Sanibel
45 Barkley Cir, Fort Myers
$?
2026026175 MLS
Prime professional office space now available for lease at 45 Barkley Circle, Fort Myers, FL. This beautifully maintained unit features 7 private offices, 3 bathrooms, and an oversized break room, ideal for a growing professional practice. The space has been freshly painted throughout and is move-in ready. Previously built for a dental office. Building highlights include a new roof replacement (2025), 4 A/C units ensuring optimal climate control, and 15 parking spaces including 4 covered spaces for staff or clients. Situated in one of Fort Myers' most sought-after corridors for professional and medical offices, this location offers unmatched convenience with easy access to major roadways and surrounding amenities. Do not miss this opportunity to position your business in a premier professional setting. Schedule a showing today!

45 Barkley Cir, Fort Myers
1416 Lafayette St Unit 2, Cape Coral
$1,600
2026026507 MLS
Prime commercial rental opportunity in the heart of Downtown Cape Coral with Unit 2 now available for lease. This newly renovated space offers a private restroom, a welcoming front office or reception area, and a separate rear air-conditioned workspace or storage area, providing a flexible layout suitable for a variety of business needs. Recent improvements to the property include new A/C systems, updated electrical and plumbing, and a new roof, giving tenants the benefit of a modernized and well-maintained environment. Ideal for professional offices, service-based businesses, retail operations, creative studios, and many other commercial uses, located within the Community Redevelopment Area (CRA) district and enjoys excellent visibility with steady vehicle and pedestrian traffic. The property is just minutes from Cape Coral Parkway, the Cape Coral Bridge, and the many restaurants, shops, and amenities that make Downtown Cape Coral a thriving business destination. On-site parking, along with ample street parking, provides convenient access for both customers and employees, making this an outstanding opportunity to establish or expand your business in one of Cape Coral's most desirable commercial corridors.

1416 Lafayette St Unit 2, Cape Coral
16521 San Carlos Blvd Unit 120, Fort Myers
$17
2026025863 MLS
Suite #120 is on the 1st Floor with 800± SF including open floorplan, a private office and one restroom. It is located in South Fort Myers between Summerlin Rd and Kelly Rd. There is also a carport included. Plenty of parking. The building consists of (8) office suites. Position your business in a professional, accessible setting at Zycron Professional Center in Fort Myers, Florida near Sanibel. This well-maintained two-story office building offers a suite on the first floor with an open work area, one private office, and a private restroom, creating a functional and efficient layout for a variety of users. The property delivers convenience and accessibility with elevator access to the second floor for visitors or future expansion needs. Situated along San Carlos Boulevard in a high-visibility corridor, the location benefits from strong traffic counts and easy access to major roads including Summerlin Road and Kelly Road. This vibrant South Fort Myers area connects directly to coastal communities, shopping destinations, and residential neighborhoods, supporting a thriving business environment. Prominent signage opportunities allow your business to capture attention in a busy marketplace with 14,500 daily traffic counts reported nearby. With robust surrounding demographics and proximity to key commercial and hospitality hubs, this office setting combines functionality with accessibility and supports long-term operational success for professional users seeking a prime Fort Myers location.

16521 San Carlos Blvd Unit 120, Fort Myers
1010 Ne 9th St Unit A, Cape Coral
$895,000
2026023460 MLS
Prime Cape Coral Commercial Opportunity – Exceptional investment opportunity in the rapidly growing Northeast Cape Coral area! Located at 1010 NE 9th Street Unit A, Cape Coral, FL 33909, this commercial property offers excellent visibility, easy access, and a strategic location near major roadways, residential communities, and expanding commercial developments. The sale includes the existing commercial property. Whether you're an owner-user, investor, or developer, this package presents a rare chance to secure additional land in one of Cape Coral's fastest-growing corridors. With continued growth throughout Cape Coral and increasing demand for commercial space, this property offers outstanding potential for a variety of business uses. Don't miss the opportunity to own in a prime location with endless possibilities for future growth and income generation.

1010 Ne 9th St Unit A, Cape Coral
4072 Stringfellow Rd, St. James City
$229,000
2026024007 MLS
Commercial lot on Stringfellow Rd In St James City on Pine Island. Uncleared 2.27 Acres total, CS commercial zoned. Pine Island is the Largest Island in Florida and is surrounded on the East by Cape Coral/Ft Myers and to the west by Sanibel/Captiva and the outer Islands...Tropical Island Main Road visibility - Great future growth potential and at this Great Price !!!! There are two other parcels listed that are contiguous to this parcel for a total of 9 acres (2026024005 & 2026024006) Bring your sunglasses & sun tan lotion and check out this 5 Acre Commercial property TODAY.

4072 Stringfellow Rd, St. James City
4026 Stringfellow Rd, St. James City
$500,000
2026024006 MLS
Commercial lot on Stringfellow Rd In St James City on Pine Island. Uncleared 5 Acres total, C-1 commercial zoned. Pine Island is the Largest Island in Florida and is surrounded on the East by Cape Coral/Ft Myers and to the west by Sanibel/Captiva and the outer Islands...Tropical Island Main Road visibility - Great future growth potential and at this Great Price !!!! There are two other parcels listed that are contiguous to this parcel for a total of 9 acres (2026024005 & 2026024007) Bring your sunglasses & sun tan lotion and check out this 5 Acre Commercial property TODAY.

4026 Stringfellow Rd, St. James City
3960 Stringfellow Rd, St. James City
$189,000
2026024005 MLS
Commercial lot on Stringfellow Rd In St James City on Pine Island. Uncleared 1.81 Acres total, C-1 commercial zoned. Pine Island is the Largest Island in Florida and is surrounded on the East by Cape Coral/Ft Myers and to the west by Sanibel/Captiva and the outer Islands...Tropical Island Main Road visibility - Great future growth potential and at this Great Price !!!! There are two other parcels listed that are contiguous to this parcel for a total of 9 acres (2026024006 & 2026024007) Bring your sunglasses & sun tan lotion and check out this 5 Acre Commercial property TODAY.

3960 Stringfellow Rd, St. James City
2251 Grand Ave, Fort Myers
$1,999,999
2026024071 MLS
Positioned in the heart of rapidly revitalizing Downtown Fort Myers, this unique mixed-use property offers exceptional income and redevelopment potential in one of Southwest Florida's most dynamic growth corridors. Conveniently located directly adjacent to the renowned Fort Myers Skatium, a popular destination featuring an ice skating arena, athletic gymnasium, and fitness center, the property benefits from consistent traffic and strong community presence. Adjacent property 2109 Crawford included with sale for $1,490,000. The building features three distinct income-producing spaces. Upstairs, you'll find two beautifully renovated residential condominium units, including a spacious 3-bedroom, 2-bath open-concept residence and a well-appointed 2-bedroom, 2-bath unit. Both offer modern finishes and comfortable living accommodations in a highly desirable downtown setting. The ground floor is currently configured as a music studio, providing flexible commercial space suitable for creative professionals, retail, office, wellness, or specialty business use. A fully fenced parking lot with approximately 10 dedicated parking spaces adds significant value, offering convenience, security, and ample parking for tenants, customers, and guests. Downtown Fort Myers is undergoing a remarkable transformation, with luxury residential developments, expanded hospitality offerings, and major infrastructure investments reshaping the city's skyline and fueling economic growth. This property presents an outstanding opportunity for investors, owner-users, or developers seeking a foothold in one of Florida's most exciting urban markets. Don't miss the chance to own a versatile mixed-use asset in a thriving downtown location with endless possibilities.

2251 Grand Ave, Fort Myers
no property photo
$16
2026022859 MLS
Professional office space available in a high-visibility location just off College Parkway, directly across from Florida SouthWestern State College. The property is positioned along a major six-lane artery serving traffic to and from Cape Coral, offering excellent exposure and convenient access within one of Fort Myers’ established commercial corridors. The available space includes Suite 5A and Suite 5B, with Suite 5A containing approximately 890 SF and Suite 5B containing approximately 1,797 SF. Offered at a base rent rate of $16.50/SF/YR with a NNN of $7.48/SF/YR. Ownership will consider dividing for the right tenant. Recent building improvements include all new rooftop A/C units. Ownership also reports that the property has maintained tenant operations through the past four hurricanes, with no tenant downtime other than city electric interruptions.

6360 Presidential Ct, Fort Myers
2341 Palm Ridge Rd Unit A, B, C, Sanibel
$1,495,000
2026022434 MLS
Premier opportunity to acquire a highly visible commercial property in the heart of Sanibel Island’s Town Center corridor.Located at 2341 Palm Ridge Road near CVS and Sanibel City Center, this professionally configured commercial building consists of three separate folios/units currently operating as one combined space with a long-standing professional office occupant in place. The property offers approximately 2,827 square feet with excellent accessibility,strong visibility, and 22 on-site parking spaces. The existing layout includes multiple private offices, conference space, reception area, kitchenette, restrooms, and flexible work areas suitable for a variety of professional and commercial uses including legal, financial, consulting, design, real estate, wellness, and other service-oriented businesses.Current occupancy provides immediate income with future flexibility for an owner-user, investor, continued tenancy,or potential multi-suite configuration. Historical records and prior marketing reference Units A, B & C with separate folios and individual tax parcels. Positioned just off Periwinkle Way within one of Sanibel’s most established commercial corridors, this is a rare opportunity to secure a well-located island commercial asset with long-term value and flexibility.

2341 Palm Ridge Rd Unit A, B, C, Sanibel
1339 Santos Rd, Fort Myers Beach
$1,199,000
2026021030 MLS
INVESTORS, DON’T MISS THIS RARE OPPORTUNITY! This prime 5,997+/- sq. ft. waterfront lot is ideally located within the highly desirable Santos Zoning District, offering endless potential and income-producing possibilities. Allowable uses include an office with a residential apartment above, duplex, bed and breakfast, single-family residence, water taxi operation, and more (please request the Zoning Verification Letter for complete details; agents can access the ZVL and survey in the MLS). Whether you’re looking to build or invest, this property offers exceptional potential for strong returns—especially with its location in the highly sought-after WEEKLY RENTAL DISTRICT, creating incredible short-term rental income opportunities. Perfectly situated directly across from the iconic Lani Kai Island Resort and just steps from the beach, Margaritaville Beach Resort, popular dining, and shopping. This property combines unbeatable location with unmatched versatility. A truly unique investment opportunity in the heart of Fort Myers Beach!

1339 Santos Rd, Fort Myers Beach
10530 Stringfellow Rd, Bokeelia
$1,975,000
2026020981 MLS
Highest traffic count on Pine Isalnd

10530 Stringfellow Rd, Bokeelia
4968 Royal Gulf Cir, Fort Myers
$399,000
2026020327 MLS
Great opportunity to purchase this medical office located in the heart of Fort Myers and only blocks away from the new Lee Health Hospital projected to open in 2028. This unit offers a reception area, admin office with storage/file room, three treatment rooms, open flex space with sinks, kitchenette, outdoor terrace under truss and ample parking. Pylon signage available.

4968 Royal Gulf Cir, Fort Myers
no property photo
$?
2026020407 MLS
Professional business complex in the heart of Fort Myers Available for immediate occupancy Professional or medical office spaces with multiple layouts Central location provides easy access Property is equidistant to all the main arteries of Fort Myers: US-41, Colonial Blvd.? and Winkler Ave Plenty of parking Drive around access Unit 15 can be built to Tenants specifications - 2,150/SF Unit 6 - 1,000/SF

3660 Central Ave Unit 6, Fort Myers
27901 Bonita Breeze Way Unit 408, Bonita Springs
$595,000
2026019505 MLS
Discover Bonita Breeze Auto Condos, an unparalleled luxury storage experience designed for the discerning collector. Located on Bonita Beach Rd less than 1 mile from the beachfront. Complex of meticulously crafted buildings house 25 exclusive, climate-controlled commercial condominium units, perfect for safeguarding your prized cars, boats, RVs, or other personal treasures. All owners have 24 hour gate access. Presently Unit 408 is available (20'W x 43'L-860 sqft) with a 12' x 14' commercial hurricane rated power garage door, providing ample room for a variety of vehicles, boat or collectibles. These premium units offer a suite of top-tier amenities : epoxy finished flecked flooring, high-speed internet availability , cable TV compatibility, insulated walls, and a versatile open space concept. Unit 408 is "plumbing-ready" to construct bathroom or mezzanine. Indulge in the ultimate sanctuary for your valuable assets, where security, comfort, and sophistication meet. Peace of Mind knowing your prized autos are protected is worthwhile as the complex did not suffer any water or wind damage during historical Hurricane Ian. ("X" Flood Zone)

27901 Bonita Breeze Way Unit 408, Bonita Springs
Fort Myers
$?
226016604 MLS
This free standing office building is located along McGregor Blvd with over 100 feet of frontage and just minutes from Downtown Ft. Myers. Offering 5 private offices with the option of using an additional space as a conference room. There is a reception area as well. The space was recently painted and new COREtec wood plank flooring was installed.

Fort Myers
2959 Oleander St, St. James City
$750,000
2026016434 MLS
Here is your chance to own the prime piece of real estate in the prime location in Pine Island's St. James City. Positioned along Stringfellow Road, the primary and only north–south artery serving Pine Island, the property benefits from consistent daily traffic of approximately 4,000+ vehicles per day. Unlike traditional high-traffic corridors, this location captures a captive audience of residents, contractors, and visitors traveling to and from the southern end of the island, making it ideal for service-oriented and destination-based businesses. Zoned C-1 with a Limited Commercial Overlay (LCO), the property allows for a wide range of neighborhood-serving commercial uses while maintaining the low-density coastal character that defines Pine Island. This zoning is ideal for retail, restaurant, office, or marine-related uses that cater to the area’s strong local and boating community.

2959 Oleander St, St. James City
2400 1st St Unit 102, Fort Myers
$5,850
2026016455 MLS
MOVE IN READY! Discover all that the Historic Downtown River District has to offer with this AMAZING FIRST FLOOR space located on LEE STREET! Surrounded by established businesses, new development, foot traffic, a great location and even 500 apartments are built within walking distance. Imagine the possibilities for your business. Large windows grace the West side of the space with a spacious front porch allowing for a relaxing workspace full of natural light. There is a private suite restroom and small kitchen sink area as well! The first floor also common area restrooms, well maintained elevator (front of building), a rear exit/entrance and more. If you are looking for exposure, window frontage, and foot traffic; this space is perfect for you. If you have not experienced the historic district, now is your chance. This modified gross lease has no additional charges outside of your standard business expenses. (electric and water are included), CAM is included with the monthly rental rate. Tenant is responsible for 3rd party utilities (cable, internet, phone) Common areas are professionally cleaned, On-site Building Management as well!

2400 1st St Unit 102, Fort Myers
9200 Estero Park Commons Blvd Unit 5, Estero
$?
226015103 MLS
Available: Unit 5. Size: 1,890± SF. Lease Rate: $21.00 PSF + NNN (est. $8.35 PSF). Available: October 1, 2026. STE Features: 4 offices, conference room, open work area, breakroom/file room and 2 restrooms. PROPERTY OVERVIEW: Professionally managed office / medical office campus fronting Corkscrew Road. Direct access to fiber network. Located just off Corkscrew Road with close access to I-75 and US-41. Adjacent to Village of Estero Administrative Offices and Estero Community Park.

9200 Estero Park Commons Blvd Unit 5, Estero
12611 Bonita Beach Se Rd, Bonita Springs
$51
226015028 MLS
Hard-to-find small retail space at Bonita's newest retail address! Building complete - moving tenants in now! 800sf +/- with direct frontage on Bonita Beach Road. Delivered as a vanilla shell with HVAC and handicap bathroom - ready on or about June 1st, 2026. High ceilings, lots of natural light, plenty of parking, and large sign panel. Offered at $3,900/month gross (includes CAM).

12611 Bonita Beach Se Rd, Bonita Springs
9420 Bonita Beach Se Rd, Bonita Springs
$?
226014664 MLS
9420 Bonita Beach Road SE is a Class A Office Building with an excellent window line and lots of light! Use is Upscale Office.

9420 Bonita Beach Se Rd, Bonita Springs
4849 Palm Beach Blvd, Fort Myers
$780,000
2026014799 MLS
IN THE HUGE OF SEVERAL COMMERCIAL AREA. Large versatile commercial property with direct Palm Beach Blvd frontage, 2 minutes to the Interstate Highway I-75. If you wish to expand this property, you can purchase the residential home at 51 Alameda Ave, Fort Myers, FL 33905 (0.38 acre), which is located adjacent to these commercial lot.

4849 Palm Beach Blvd, Fort Myers
13515 Bell Tower Dr, Fort Myers
$?
222013967 MLS
This Class “B” office building is ideal for medical, healthcare, or professional office use. Located in central Fort Myers at Bell Tower Shops, it's near popular venues like Nordstrom Rack, Capital Grille, Dave & Buster’s, Ulta, The Fresh Market, Regal Belltower, Florida Trust, & Wells Fargo Advisors. The property features a signalized intersection, dedicated turn lane, pylon signage, and one elevator. There are 91 shared parking spaces for both 13515 and 13525 Bell Tower Dr. Available space options are: 2nd Floor: 7,080 SF at $22.00 PSF + $8.75 CAM and 3rd Floor: 6,473 SF at $22.00 PSF + $8.75 CAM.

13515 Bell Tower Dr, Fort Myers